Evolving ideas

March 28, 2009

Pleiotropy

Filed under: Evolutionary theory — Ben @ 7:19 pm

I’ve posted a few times on pleiotropy. Pleiotropy, or the multiple causal connections that a given gene is involved in, is the bête noire of evolution by selection because it increases the probability that a mutation at that gene will be deleterious (even though it may be beneficial within one context). Modularity is required at the gene level to allow functional change to occur by selection and this has motivated some to propose that cis-regulatory elements (CREs) are crucial to the evolution and development of form.

But modularity can also occur at the level of genetic networks and it is often asserted that such networks can be co-opted in their entirety to fulfill novel (non-homologous) functions. In the context of testing this idea, this recent article addresses the consequences of this for the pleiotropy of CREs. If network co-option really is that common, pleiotropic CREs will also be common at least among those genes that tend to be found within networks rather than upstream. This seems to be a nice example of entrenchment in evolution.

March 27, 2009

Creative thinking

Filed under: Uncategorized — Ben @ 10:46 pm

There is a pattern in the way I respond to world events with high penetrance in the news. I tend to become emotional and ideologically minded, then analytical and anti-ideological. The financial and economic situation is no exception and it seems to offer plenty of opportunities for my sort of confusion. Here is a chance to push a social democratic agenda, to challenge market fundamentalism – the argument for market failure seems compelling. On the other hand, I am losing confidence in the stimulus: both as a concept championed by economic “science” and as a policy carried out by crony capitalists with friends in certain industries. I am entering my sceptical, anti-ideological phase – totally free markets are footling abstractions, real markets are fallible, real regulation inadequate, and the re-colonisation of the markets by governments not entirely benign. The disappointingly minimal conclusion seems to be that highly abstracted financial markets are negative sum or at least dangerously unpredictable (perhaps because of dangerous levels of prediction in them, after Nassim Nicholas Taleb). So while we can say that markets are engines of growth (and defend some level of abstraction in them), none of the big -isms offer much to add to or challenge this view and we must muddle along and cope with some of the absurd consequences of the dominance of betting in our economy (see this article for a specific and complex example).

But this recent piece has got me thinking about whether a more creative response is possible. The open source movement has made inroads beyond software into other social spheres (certainly into science where PLoS journals are flagships) and seems to offer a genuinely novel approach to production. Just as the market solves the tragedy of the commons, so open source approaches offer a solution to the tragedy of the anticommons (wherein production is limited because ownership of necessary components is distributed between companies each of which values their asset(s) at a price commensurate with sufficiency). And since open source approaches are decentralised they seem part of the solution for the burgeoning energy costs of the growing networks that support human society. The reduced transaction costs of the internet seem to offer a way to reinforce cooperation and more research is clearly needed to explore which factors drive and which factors limit this. Perhaps then we can take some of these ideas offline and into the wider world to produce robust and sustainable economies.

March 25, 2009

Adaptive acquired characteristics are genetically primed but not assimilated

Filed under: Evolutionary theory — Ben @ 6:33 pm

Post Author: John Jacob Lyons

In their book, “The Four Dimensions of Evolution”, the Waddington ‘canalization’ explanation of the genetic assimilation of adaptive acquired characteristics is referenced (p.262) and tacitly accepted by Eva Jablonka and her co-author, Marion Lamb. I don’t find this explanation at all convincing and want to propose my own explanation. I suggest that adaptive acquired characteristics are always positively and causally correlated with concomitant, genetically generated propensities. These propensities gradually become more prevalent in the gene-pool because of the success of the positively correlated acquired characteristic. In time, the organism will appear to be primed to acquire the adaptive characteristic. It is suggested that examples in humans are language and religion.

Suppose that a particular mutation (M) that appears at generation n increases the capacity to learn an adaptive behaviour (AB). AB will have a selective advantage and consequently the relative frequency of M in the population will increase in generation n+1. This will, in turn, increase the frequency of AB in this generation. So long as AB remains adaptive, this positive feedback loop will, over evolutionary time, lead to all organisms in the population having mutation M and exhibiting adaptive behaviour AB. Additionally, selective pressure will result in AB appearing earlier and earlier in the lifetime of organisms. In due course, it will appear that all organisms in the species are primed to acquire the AB.

As stated, I believe that two examples of this process in humans are language and religion. This would account for the innate ‘Language Acquisition Device’ hypothesized by Noam Chomsky and Precocious Religious Belief hypothesized and empirically demonstrated by, among others, Justin Barrett (Centre for Anthropology and Mind, Oxford University). I don’t believe that an adaptive acquired characteristic is ever genetically assimilated as proposed by Waddington. In other words, I don’t accept that the Weismann Barrier between somatic and germ cells is ever crossed in these circumstances. Rather it is as if the constituents of the genetic soil, as it were, are gradually optimized to promote the germination and growth of the AB seed. In the case of religion, the seed of belief/ faith may be provided by the parent explaining to the child that their sadly expired pet kitten, Tiddles, is now “with god in heaven” and reinforced by similar references later on. In language, the innate universal grammar proposed by Chomsky and others, may be characterized in a similar way with the heard phonemes, words, syntax and grammatical exceptions of the native language providing the seeds.

It is also suggested that the niche construction and extensions to phenotype seen in many species of animal may also have a similar origin. These could well have originated as behaviours that proved to be adaptive and that, eventually, resulted in the concomitant, positively correlated and genetically mediated allele-sets becoming ubiquitous in the species. These would then have primed the young organism to reproduce the behaviour with minimal exposure to the behaviour by others.

Powered by WordPress