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Dr Katja Rietdorf

Profile summary

  • Research Staff
  • Research Investment Fellow
  • Faculty of Science
  • Department of Life, Health & Chemical Sciences
  • katja.rietdorf

Research Activity

Externally funded projects

Characterising The Response Of Foamy Alveolar Macrophages To Inhaled Drug Particulates - Phase II

RoleStart dateEnd dateFunding source
Co-investigator16/Jan/201515/Jan/2018NC3Rs (National Centre for the Replacement Refinement and Reduction of Animals in Research)
Lung diseases such as asthma and chronic obstructive pulmonary disease (COPD) affect the lives of millions of people in the UK. Whilst the number of patients diagnosed with lung disease increases each year, the treatments available have changed very little over the past 30 years, despite large investment from pharmaceutical companies for the development of new treatments. One of the main reasons that many new medicines have not reached the market is the limited understanding of how the immune system in the lungs responds to the inhalation of therapeutic drug powders. Additionally, current methods used to test the safety of new inhaled medicines, rely on animal models which may not accurately predict safety in humans. Regulatory bodies are therefore unable to approve new medicines that appear to sensitise the immune system in animal models, despite not knowing fully if these observations are adverse in human patients. This project aims to better characterise inflammatory responses in the lung to inhaled medicines. Commercially available cell based models of the lung will be used, and imaging, biological and analytical tools will be employed to determine the reactions to inhaled medicines. The ultimate goal will be to use non-animal methods to provide an in depth understanding of the immune responses in the lung to reduce the numbers of animal experiments required to achieve an accurate prediction of the safety of new inhaled medicines in humans.

Publications

Unifying principles of calcium wave propagation — Insights from a three-dimensional model for atrial myocytes (2015-09)
Thul, R.; Rietdorf, K.; Bootman, M. D. and Coombes, S.
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1853(9) (pp. 2131-2143)
Nicotinic acid adenine dinucleotide phosphate (NAADP) and endolysosomal two-pore channels modulate membrane excitability and stimulus-secretion coupling in mouse pancreatic β cells (2015-08-28)
Arredouani, Abdelilah; Ruas, Margarida; Collins, Stephan C.; Parkesh, Raman; Clough, Frederick; Pillinger, Toby; Coltart, George; Rietdorf, Katja; Royle, Andrew; Johnson, Paul; Braun, Matthias; Zhang, Quan; Sones, William; Shimomura, Kenju; Morgan, Anthony J.; Lewis, Alexander M.; Chuang, Kai-Ting; Tunn, Ruth; Gadea, Joaquin; Teboul, Lydia; Heister, Paula M.; Tynan, Patricia W.; Bellomo, Elisa A.; Rutter, Guy A.; Rorsman, Patrik; Churchill, Grant C.; Parrington, John and Galione, Antony
Journal of Biological Chemistry, 290(35) (pp. 21376-21392)
Pulmonary vein sleeve cell excitation–contraction-coupling becomes dysynchronized by spontaneous calcium transients (2015)
Rietdorf, Katja; Masoud, Said; McDonald, Fraser; Sanderson, Michael J. and Bootman, Martin D.
Biochemical Society Transactions, 43(3) (pp. 410-416)
Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma (2015)
Yarova, Polina L.; Stewart, Alecia L.; Sathish, Venkatachalem ; Britt, Rodney D.; Thompson, Michael A.; Lowe, Alexander P. P.; Freeman, Michelle; Aravamudan, Bharathi; Kita, Hirohito; Brennan, Sarah C.; Schepelmann, Martin ; Davies, Thomas; Yung, Sun; Cholisoh, Zakky; Kidd, Emma J.; Ford, William R.; Broadley, Kenneth J.; Rietdorf, Katja; Chang, Wenhan; Bin Khayat, Mohd E.; Ward, Donald T.; Corrigan, Christopher J.; T. Ward, Jeremy P.; Kemp, Paul J.; Pabelick, Christina M.; Prakash, Y. S. and Riccardi, Daniela
Science Translational Medicine, 7(284) (284ra60)
Reconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+ (2014-05-20)
Pitt, Samantha J.; Lam, Andy K. M.; Rietdorf, Katja; Galione, Antony and Sitsapesan, Rebecca
Science Signaling, 7, Article ra46(326)
Spontaneous, pro-arrhythmic calcium signals disrupt electrical pacing in mouse pulmonary vein sleeve cells (2014)
Rietdorf, Katja; Bootman, Martin and Sanderson, Michael J.
PLoS ONE, 9, Article e88649(2)
Loading fluorescent Ca2+ indicators into living cells (2013-02)
Bootman, Martin D.; Rietdorf, Katja; Collins, Tony; Walker, Simon and Sanderson, Michael
Cold Spring Harbor Protocols, 2013, Article pdb.prot072801(2)
Ca2+-sensitive fluorescent dyes and intracellular Ca2+ imaging (2013-02)
Bootman, Martin D.; Rietdorf, Katja; Collins, Tony; Walker, Simon and Sanderson, Michael
Cold Spring Harbor Protocols, 2013, Article pdb.top066050(2)
Converting fluorescence data into Ca2+ concentration (2013)
Bootman, Martin D.; Rietdorf, Katja; Collins, Tony; Walker, Simon and Sanderson, Michael
Cold Spring Harbor Protocols, 2013(2) (pp. 126-129)
Loss of activity mutations in phospholipase C zeta (PLCζ) abolishes calcium oscillatory ability of human recombinant protein in mouse oocytes (2011-12)
Kashir, Junaid; Jones, Celine; Lee, Hoi Chang; Rietdorf, Katja; Nikiforaki, Dimitra; Durrans, Claire; Ruas, Margarida; Tee, Sze Tian; Heindryckx, Bjorn; Galione, Antony; De Sutter, Petra; Fissore, Rafael A.; Parrington, John and Coward, Kevin
Human Reproduction, 26(12) (pp. 3372-87)
Two-pore channels form homo- and heterodimers (2011-10-28)
Rietdorf, Katja; Funnell, Tim M.; Ruas, Margarida; Heinemann, Jennifer; Parrington, John and Galione, Antony
The Journal of Biological Chemistry, 286(43) (pp. 37058-37062)
TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+ (2010-11-05)
Pitt, Samantha J.; Funnell, Tim M.; Sitsapesan, Mano; Venturi, Elisa; Rietdorf, Katja; Ruas, Margarida; Ganesan, A.; Gosain, Rajendra; Churchill, Grant C.; Zhu, Michael X.; Parrington, John; Galione, Antony and Sitsapesan, Rebecca
The Journal of Biological Chemistry, 285(45) (pp. 35039-46)
Purified TPC isoforms form NAADP receptors with distinct roles for Ca2+ signaling and endolysosomal trafficking (2010-04-27)
Ruas, Margarida; Rietdorf, Katja; Arredouani, Abdelilah; Davis, Lianne C; Lloyd-Evans, Emyr; Koegel, Heidi; Funnell, Timothy M; Morgan, Anthony J; Ward, John A; Watanabe, Keiko; Cheng, Xiaotong; Churchill, Grant C; Zhu, Michael X; Platt, Frances M; Wessel, Gary M; Parrington, John and Galione, Antony
Current Biology, 20(8) (pp. 703-709)
NAADP mobilizes calcium from acidic organelles through two-pore channels (2009-05-28)
Calcraft, Peter J.; Ruas, Margarida; Pan, Zui; Cheng, Xiaotong; Arredouani, Abdelilah; Hao, Xuemei; Tang, Jisen; Rietdorf, Katja; Teboul, Lydia; Chuang, Kai-Ting; Lin, Peihui; Xiao, Rui; Wang, Chunbo; Zhu, Yingmin; Lin, Yakang; Wyatt, Christopher N.; Parrington, John; Ma, Jianjie; Evans, A. Mark; Galione, Antony and Zhu, Michael X.
Nature, 459(7246) (pp. 596-600)
Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis (2008-02-19)
Szado, Tania; Vanderheyden, Veerle; Parys, Jan B.; De Smedt, Humbert; Rietdorf, Katja; Kotelevets, Larissa; Chastre, Eric; Khan, Farid; Landegren, Ulf; Söderberg, Ola; Bootman, Martin D. and Roderick, H. Llewelyn
Proceedings of the National Academy of Sciences of the United States of America, 105(7) (pp. 2427-2432)
Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins (2004-01-28)
Kasri, Nael Nadif; Holmes, Anthony M.; Bultynck, Geert; Parys, Jan B.; Bootman, Martin; Rietdorf, Katja; Missiaen, Ludwig; McDonald, Fraser; De Smedt, Humbert; Conway, Stuart J.; Holmes, Andrew B.; Berridge, Michael J. and Roderick, H. Llewelyn
The EMBO Journal, 23(2) (pp. 312-21)
Interactions between epicardial adipose tissue and cardiomyocytes: results from a 3D co-culture system (2015-12-17)
Rietdorf, Katja and MacQueen, Hilary
In : Pharmacology 2015 (British Pharmacological Society) (15-17 December 2015, London)
Ageing-induced ultrastructural changes of mitochondria of pulmonary vein sleeve cells (2015)
Masoud, Said; McDonald, Fraser; Bootman, Martin and Rietdorf, Katja
In : Physiology 2015 (6-8 July 2015, Cardiff)
Inhibition of calcium release from InsP3Rs triggers autophagy (2015)
Chehab, Tala; Rietdorf, Katja; Parys, Jan; Bultynck, Geert and Bootman, Martin
In : Physiology 2015 (6-8 July 2015, Cardiff)
Effect of calcium-phosphate crystals on intracellular calcium homeostasis and viability of smooth muscle cell (2015)
Sharma, G.; Rietdorf, K.; Proudfoot, D.; McDonald, F. and Bootman, M.
In : Physiology 2015 (6-8 July 2015, Cardiff, UK)
Intracellular calcium has a dual role in the regulation of autophagy (2015)
Chehab, Tala; Rietdorf, Katja; Parys, Jan B.; Bultynck, Geert and Bootman, Martin
In : 6th ECS Workshop: Calcium and Cell Fate (21-24 June 2015, Seillac, France)
How does fat cause heart diseases? Effects of epicardial adipocytes on cardiomyocyte signalling and contractility (2015)
Rietdorf, Katja; MacQueen, Hilary and Bootman, Martin
In : Physiology 2015 (6-8 July 2015, Cardiff)
How cells outside the heart can affect the heart beat: The role of pulmonary vein sleeve cells for the development of atrial fibrillation (2015)
Rietdorf, Katja; Masoud, Said; McDonald, Fraser and Bootman, Martin
In : Gordon Conference on Calcium Signalling (7-12 June 2015, Newry, Maine, USA)
Inhibition of InsP3 receptor signalling induces autophagy (2014-10-09)
Chehab, Tala; Rietdorf, Katja; Parys, Jan B.; Bultynck, Geert and Bootman, Martin D.
In : Calcium Signalling: The Next Generation (9-10 October 2014, London, UK)
A comparative study into the ultrastructure changes of atrial myocytes, pulmonary vein sleeve cells and ventricular myocytes during ageing (2014-10-09)
Masoud, Said R.; McDonald, Fraser; Bootman, Martin D. and Rietdorf, Katja
In : Calcium Signalling: The Next Generation (9-10 October 2014, London, UK)
Spontaneous Ca2+ signalling and ultrastructural changes in pulmonary vein sleeve cells during ageing – risk factors for atrial fibrillation? (2014-10-09)
Masoud, Said; Bootman, Martin D.; McDonald, Fraser and Rietdorf, Katja
In : Calcium Signalling: The Next Generation (9-10 October 2014, London, UK)
Novel improved Ca2+ indicator dyes on the market-a comparative study of novel Ca2+ indicators with fluo-4 (2014-10-09)
Rietdorf, Katja; Chehab, Tala; Allman, Sarah and Bootman, Martin D.
In : Calcium Signalling: The Next Generation (9-10 October 2014, London, UK)
Spontaneous Ca2+ signalling and ultrastructural changes in pulmonary vein sleeve cells during ageing – risk factors for atrial fibrillation? (2014-09)
Rietdorf, Katja; Masoud, Said; McDonald, Fraser and Bootman, Martin
In : 13th International Meeting of the European Calcium Society (13-17 September 2014, Aixe-en-Provence, France)
Spontaneous Ca2+ signalling in pulmonary vein sleeve cells increases during ageing (2014-06)
Masoud, Said; Bootman, Martin and Rietdorf, Katja
In : Physiology 2014 (30 June - 02 July 2014, London)
Inhibition of InsP3 receptor signalling induces autophagy (2014)
Chehab, Tala; Rietdorf, Katja; Parys, Jan; Bultynck , Geert and Bootman, Martin
In : 13th International Meeting of the European Calcium Society (13-17 September 2014, Aix-en-Provence, France)
In vitro assessment of alveolar macrophage responses to inhaled particulate medicines (2014)
Hutter, V.; Murnane, D.; Rietdorf, K.; Fowler, D.; Walton, C. and Bootman, M.
In : Drug Delivery to the Lungs (DDL25) (10–12 December 2014, Edinburgh)