I started at the Open University in March 2011 working with David Male on transcriptional regulation of p-glycoprotein transporter on brain endothelium. Later on we began investigating gold nanoparticles for their potential for drug/gene delivery into the brain. This project was set up in partnership with Midatech Ltd. In 2013, I started to progress this work in my PhD project, which is aiming to broaden our understanding of mechanism of transport of nanoparticles into cells as well as to develop gold nanoparticles into promising delivery of oligonucleotides into the brain.
Since February 2016 I have been working on OU projects involving electron microscopy as I took up a permanent position within the Electron Microscope Suite at the Open University alongside finishing my PhD.
Nanomedicine, nanoparticles, blood-brain barrier, cell biology, electron microscopy.
Operating transmission electron microscopes and processing in vitro samples for electron microscopy.
Gromnicova, Radka; Yilmaz, Canan Ugur; Orhan, Nurcan; Kaya, Mehmet; Davies, Heather; Williams, Phil; Romero, Ignacio A.; Sharrack, Basil and Male, David
Nanomedicine, 11(6) (pp. 617-625)
A three-dimensional model of the human blood-brain barrier to analyse the transport of nanoparticles and astrocyte/endothelial interactions (2016-01-21)
Reddy, P; Gromnicova, Radka; Davies, Heather; Phillips, James; Romero, Ignacio A and Male, David
F1000Research, 4, Article 1279
Transport of Gold Nanoparticles by Vascular Endothelium from Different Human Tissues (2016)
Gromnicova, Radka; Kaya, Mehmet; Romero, Ignacio A.; Williams, Phil; Satchell, Simon; Sharrack, Basil and Male, David
PLoS ONE, 11, Article e0161610(8)
Zinc-imidazolate polymers (ZIPs) as a potential carrier to brain capillary endothelial cells (2015-10-26)
Chiacchia, M.; Cerutti, C.; Gromnicova, R.; Rietdorf, K.; Romero, I.A. and Bradshaw, D.
Journal of Materials Chemistry B, 3(46) (pp. 9053-9059)
Glucose-coated gold nanoparticles transfer across human brain endothelium and enter astrocytes in vitro (2013-12-05)
Gromnicova, Radka; Davies, Heather A.; Sreekanthreddy, Pedagannganagari; Romero, Ignacio A.; Lund, Torben; Roitt, Ivan M.; Phillips, James B. and Male, David K.
PLoS ONE, 8, Article e81043(12)
Transcriptional control of the multi-drug transporter ABCB1 by transcription factor Sp3 in different human tissues (2012-10)
Gromnicova, Radka; Romero, Ignacio A and Male, David
PLoS ONE, 7, Article e48189(10)
Male, David; Gromnicova, Radka and Mcquaid, Conor
In: Al-Jamal, Khuloud ed. Nanotechnology and the Brain. International Review of Neurobiology (130) (pp. 155-189)
ISBN : 978-0-12-804636-4 | Publisher : Elsevier | Published : London