Kerry Murphy is an I.B. Diplomat holder (UWCA), has an honours degree in Physiology from Dundee University and a PhD in Neurophysiology from University College, London. He started his post-doctoral life as a Departmental Demonstrator in CNS Pharmacology at the University of Oxford before joining Prof Tim Bliss FRS as a MRC Research Fellow at the National Institute for Medical Research in London. From London he later moved to East Anglia as a Cambridge University Pharmacology Fellow before taking up his current post at the Open University.
Keywords: Huntington's disease, CAG triplet repeat disorders, synaptic plasticity, dopamine, cognition, learning and memory, long-term potentiation (LTP) and long-term depression (LTD), electrophysiology
Kerry was recently asked to comment on the key issues that drive his research:
'One of the greatest challenges facing society today is the defeat of neurodegenerative brain disease. As our population ages, more of us will be afflicted by devastating brain disorders such as Alzheimer's disease, Parkinson's disease and senile dementia - neurodegenerative conditions that rob us of the ability to think, to learn and to remember. Until very recently, these diseases remained intractable to modern science. However, rapid advances in molecular genetics and the advent of transgenic models for some of these diseases, has now made it possible, for the first time, to study the pathogenic process and examine how it affects the physiology of the brain, especially those mechanisms involved in learning and memory. It is hoped that studies of this type will aid the development of new and effective treatments in the fight against brain disease. To this end, my laboratory, as part of the Huntington's Disease Research Forum based at the OU, is using the latest transgenic advances to study early pathogenesis in Huntington's disease with the aim of identifying new targets for therapeutic intervention.'
Kerry is a founding member of the Huntington's Disease Research Forum based at the Open University. This group of dedicated scientists and PhD students is currently using electrophysiogical, cell culture, histological and genetic techniques to study the pathogenesis of Huntington's disease.
Recent papers published by the Huntington's Disease Research Forum:
Dallerac, Cummings, Hirst, Milnerwood and Murphy (2016) Changes in dopamine signalling do not underlie aberrant hippocampal plasticity in a mouse model of Huntington's disease. NeuroMolecular Medicine, 18, 146-153.
Dallerac, Levasseur, Vatsavayai, Milnerwood, Cummings, Kraev, Huetz, Evans, Walters, Rezaie, Cho, Hirst and Murphy (2015) Dysfunctional dopaminergic neurones in mouse models of Huntington's disease: a role for SK3 channels. Neurodegenerative diseases, 15, 93-108.
Cepda, Murphy, Parent and Levine (2014) The role of dopamine in Huntington's disease. Progress in Brain Research, 211, 235-254.
Dallerac, Vatsavayai, Cummings, Milnerwood, Peddie, Evans, Walters, Rezaie, Hirst and Murphy (2011) Impaired long-term potentiation in the prefrontal cortex of Huntington's disease mouse models: rescue by D1 dopamine receptor activation. Neurodegenerative diseases, 8 230-239.
Cummings, Milnerwood, Dallerac, Waights, Brown, Vatsavayai, Hirst and Murphy (2006) Aberrant cortical synaptic plasticity and dopaminergic dysfunction in a mouse model of huntington's disease. Human Molecular Genetics, 15 (19). pp. 2856-2868
Milnerwood, Cummings, Dallerac, Brown, Vatsavayai, Hirst, Rezaie and Murphy (2006) Early development of aberrant synaptic plasticity in a mouse model of Huntington's disease. Human Molecular Genetics, 15 (10). pp. 1690-1703
Cummings, Milnerwood, Dallerac, Vatsavayai, Hirst and Murphy (2007) Abnormal cortical synaptic plasticity in a mouse model of Huntington's disease. Brain Res Bull, 72, 103-107.
Vatsavayai, Dallerac, Milnerwood, Cummings, Rezaie, Murphy and Hirst (2007) Progressive CAG expansion in the brain of a novel R6/1-89Q mouse model of Huntington's disease with delayed phenotypic onset. Brain Res Bull. 72, 98-102.
SK299 Human biology
SK123 Understanding cancers
S294 Cell biology
SDK100 Science and health
SK277: Human biology (replaced by SK299)
SD226: Biological psychology - Exploring the brain
SK121: Understanding cardiovascular disease
SK220: Human biology & health (replaced by SK277)
PhD supervision (full-time and part-time)
|Biomedical Research Network (BRN)||Network||Faculty of Science|
|Centre for Earth, Planetary, Space and Astronomical Research (CEPSAR)||Centre||Faculty of Science|
|Role||Start date||End date||Funding source|
|Co-investigator||01/Oct/2018||30/Sep/2021||King's College London (KCLU)|
£10k for consumables from King's College London, collaboration with Dr Ellie Dommett. For Morgane Colom's studentship.