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Dr Katja Rietdorf

Profile summary

  • Central Academic Staff
  • Lecturer
  • Faculty of Science, Technology, Engineering & Mathematics
  • School of Life, Health & Chemical Sciences
  • katja.rietdorf

Professional biography

I am a cell physiologist specialising in calcium signalling and the regulation of calcium channels. My PhD was obtained in the laboratory of Bernd Walz at the University of Potsdam in Germany on the topic of ‘Signalling Pathways that Stimulate Protein and Fluid Secretion in Cockroach Salivary Glands’. This was followed by studying IP3 receptor-interacting proteins in Martin Bootman and Mike Berridge’s laboratory at The Babraham Institute in Cambridge, and the characterisation of two-pore channels (TPCs) as endolysosomal calcium channels activated by the second messenger NAADP in Antony Galione’s laboratory at Oxford University. Subsequently I joined the laboratory of Michael Sanderson at UMASS Medical School in Worcester, MA, USA and started working on a special type of cardiac cells called pulmonary vein sleeve cells (PVCs). From UMASS I moved to The Open University, first as a Research Fellow, before I became a Lecturer in Biology in 2016.

Research interests

My research focusses on the role of calcium signalling in health and disease, especially in cardiac cells. Much of my work has focussed on the regulation of intracellular calcium release channels, namely IP3 receptors and ryanodine receptors localised on the endo- or sarcoplasmic reticulum, and two-pore channels (TPCs) on endosomes and lysosomes. All the projects are done in close collaboration with Martin Bootman.

Over the past years, we have worked on a pro-arrhythmic type of cardiac myocyte that is located in the pulmonary vein, called pulmonary vein sleeve cells (PVCs). The spontaneous activity of these cells is one of the main causes of atrial fibrillation, the most common form of cardiac arrhythmia. In one of our projects, we are characterising the structural and functional changes that occur in PVCs during ageing.

Based on my interest in endolysosomal ion channels, especially TPCs, and the fact that recent work provided evidence that the activity of TPCs can modulate the function of cardiac myocytes, we are studying how lysosomal ion channels contribute to the function of healthy cardiac myocytes.

Patients suffering from a lysosomal storage disorder called CLN3 develop cardiac dysfunction during their disease progression. CLN3 belongs to a group of lysosomal storage disorders called Neuronal Ceroid Lipofuscinoses (NCLs). To study what causes the decline in the cardiac function observed in CLN3 patients, we are comparing the structure and function of iPSC-derived cardiac myocytes using cells from patients with and without mutations in the CLN3 gene, and also in mouse models.

Other projects in the laboratory study the role of calcium in autophagy, and mechanisms of vascular calcification caused by calcium-phosphate particles.

Teaching interests

Co-Chair for the Module S294: Cell Biology

Production of a novel level 2 Health Sciences Module

External collaborations

Dr Katharine Dibb, Manchester University (Studying the structure and function of PVCs)

Dr Emyr Lloyd-Evans, Cardiff University (Lysosomal calcium channels and NCLs)

Publications

Deleterious effects of calcium indicators within cells; an inconvenient truth (2018-07)
Bootman, Martin D.; Allman, Sarah; Rietdorf, Katja and Bultynck, Geert
Cell Calcium, 73 (pp. 82-87)
Constitutive IP3 signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP3 receptor disruptor BIRD-2 (2018-06-13)
Bittremieux, Mart; La Rovere, Rita M.; Akl, Haidar; Martines, Claudio; Welkenhuyzen, Kirsten; Dubron, Kathia; Baes, Myriam; Janssens, Ann; Vandenberghe, Peter; Laurenti, Luca; Rietdorf, Katja; Morciano, Giampaolo; Pinton, Paolo; Mikoshiba, Katsuhiko; Bootman, Martin D.; Efremov, Dimitar G.; De Smedt, Humbert; Parys, Jan B. and Bultynck, Geert
Cell Death & Differentiation
Investigating interactions between epicardial adipose tissue and cardiac myocytes: what can we learn from different approaches? (2017-10)
Rietdorf, Katja and MacQueen, Hilary
British Journal of Pharmacology, 174(20) (pp. 3542-3560)
The regulation of autophagy by calcium signals: Do we have a consensus? (2017-08-19)
Bootman, Martin D.; Chehab, Tala; Bultynck, Geert; Parys, Jan B. and Rietdorf, Katja
Cell Calcium, 70 (pp. 32-46)
The vascular Ca2+-sensing receptor regulates blood vessel tone and blood pressure (2016-02-01)
Schepelmann, M.; Yarova, P. L.; Lopez-Fernandez, I.; Davies, T. S.; Brennan, S. C.; Edwards, P. J.; Aggarwal, A.; Graça, J.; Rietdorf, K.; Matchkov, V.; Fenton, R. A.; Chang, W.; Krssak, M.; Stewart, A.; Broadley, K. J.; Ward, D. T.; Price, S. A..; Edwards, D. H.; Kemp, P. J. and Riccardi, D.
American Journal of Physiology - Cell Physiology, 310(3) (C193-C204)
Zinc-imidazolate polymers (ZIPs) as a potential carrier to brain capillary endothelial cells (2015-10-26)
Chiacchia, M.; Cerutti, C.; Gromnicova, R.; Rietdorf, K.; Romero, I.A. and Bradshaw, D.
Journal of Materials Chemistry B, 3(46) (pp. 9053-9059)
Unifying principles of calcium wave propagation — Insights from a three-dimensional model for atrial myocytes (2015-09)
Thul, R.; Rietdorf, K.; Bootman, M. D. and Coombes, S.
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1853(9) (pp. 2131-2143)
Nicotinic acid adenine dinucleotide phosphate (NAADP) and endolysosomal two-pore channels modulate membrane excitability and stimulus-secretion coupling in mouse pancreatic β cells (2015-08-28)
Arredouani, Abdelilah; Ruas, Margarida; Collins, Stephan C.; Parkesh, Raman; Clough, Frederick; Pillinger, Toby; Coltart, George; Rietdorf, Katja; Royle, Andrew; Johnson, Paul; Braun, Matthias; Zhang, Quan; Sones, William; Shimomura, Kenju; Morgan, Anthony J.; Lewis, Alexander M.; Chuang, Kai-Ting; Tunn, Ruth; Gadea, Joaquin; Teboul, Lydia; Heister, Paula M.; Tynan, Patricia W.; Bellomo, Elisa A.; Rutter, Guy A.; Rorsman, Patrik; Churchill, Grant C.; Parrington, John and Galione, Antony
Journal of Biological Chemistry, 290(35) (pp. 21376-21392)
Pulmonary vein sleeve cell excitation–contraction-coupling becomes dysynchronized by spontaneous calcium transients (2015)
Rietdorf, Katja; Masoud, Said; McDonald, Fraser; Sanderson, Michael J. and Bootman, Martin D.
Biochemical Society Transactions, 43(3) (pp. 410-416)
Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma (2015)
Yarova, Polina L.; Stewart, Alecia L.; Sathish, Venkatachalem; Britt, Rodney D.; Thompson, Michael A.; Lowe, Alexander P. P.; Freeman, Michelle; Aravamudan, Bharathi; Kita, Hirohito; Brennan, Sarah C.; Schepelmann, Martin; Davies, Thomas; Yung, Sun; Cholisoh, Zakky; Kidd, Emma J.; Ford, William R.; Broadley, Kenneth J.; Rietdorf, Katja; Chang, Wenhan; Bin Khayat, Mohd E.; Ward, Donald T.; Corrigan, Christopher J.; T. Ward, Jeremy P.; Kemp, Paul J.; Pabelick, Christina M.; Prakash, Y. S. and Riccardi, Daniela
Science Translational Medicine, 7(284) (284ra60)
Atrial myocytes demonstrate the diversity of cardiac calcium signalling (2015)
Bootman, Martin D. and Rietdorf, Katja
Channels, 9(5) (pp. 219-220)
Reconstituted human TPC1 is a proton-permeable ion channel and is activated by NAADP or Ca2+ (2014-05-20)
Pitt, Samantha J.; Lam, Andy K. M.; Rietdorf, Katja; Galione, Antony and Sitsapesan, Rebecca
Science Signaling, 7, Article ra46(326)
Spontaneous, pro-arrhythmic calcium signals disrupt electrical pacing in mouse pulmonary vein sleeve cells (2014)
Rietdorf, Katja; Bootman, Martin and Sanderson, Michael J.
PLoS ONE, 9, Article e88649(2)
Loading fluorescent Ca2+ indicators into living cells (2013-02)
Bootman, Martin D.; Rietdorf, Katja; Collins, Tony; Walker, Simon and Sanderson, Michael
Cold Spring Harbor Protocols, 2013, Article pdb.prot072801(2)
Ca2+-sensitive fluorescent dyes and intracellular Ca2+ imaging (2013-02)
Bootman, Martin D.; Rietdorf, Katja; Collins, Tony; Walker, Simon and Sanderson, Michael
Cold Spring Harbor Protocols, 2013, Article pdb.top066050(2)
Converting fluorescence data into Ca2+ concentration (2013)
Bootman, Martin D.; Rietdorf, Katja; Collins, Tony; Walker, Simon and Sanderson, Michael
Cold Spring Harbor Protocols, 2013(2) (pp. 126-129)
Loss of activity mutations in phospholipase C zeta (PLCζ) abolishes calcium oscillatory ability of human recombinant protein in mouse oocytes (2011-12)
Kashir, Junaid; Jones, Celine; Lee, Hoi Chang; Rietdorf, Katja; Nikiforaki, Dimitra; Durrans, Claire; Ruas, Margarida; Tee, Sze Tian; Heindryckx, Bjorn; Galione, Antony; De Sutter, Petra; Fissore, Rafael A.; Parrington, John and Coward, Kevin
Human Reproduction, 26(12) (pp. 3372-87)
Two-pore channels form homo- and heterodimers (2011-10-28)
Rietdorf, Katja; Funnell, Tim M.; Ruas, Margarida; Heinemann, Jennifer; Parrington, John and Galione, Antony
The Journal of Biological Chemistry, 286(43) (pp. 37058-37062)
TPC2 is a novel NAADP-sensitive Ca2+ release channel, operating as a dual sensor of luminal pH and Ca2+ (2010-11-05)
Pitt, Samantha J.; Funnell, Tim M.; Sitsapesan, Mano; Venturi, Elisa; Rietdorf, Katja; Ruas, Margarida; Ganesan, A.; Gosain, Rajendra; Churchill, Grant C.; Zhu, Michael X.; Parrington, John; Galione, Antony and Sitsapesan, Rebecca
The Journal of Biological Chemistry, 285(45) (pp. 35039-46)
Purified TPC isoforms form NAADP receptors with distinct roles for Ca2+ signaling and endolysosomal trafficking (2010-04-27)
Ruas, Margarida; Rietdorf, Katja; Arredouani, Abdelilah; Davis, Lianne C; Lloyd-Evans, Emyr; Koegel, Heidi; Funnell, Timothy M; Morgan, Anthony J; Ward, John A; Watanabe, Keiko; Cheng, Xiaotong; Churchill, Grant C; Zhu, Michael X; Platt, Frances M; Wessel, Gary M; Parrington, John and Galione, Antony
Current Biology, 20(8) (pp. 703-709)
NAADP mobilizes calcium from acidic organelles through two-pore channels (2009-05-28)
Calcraft, Peter J.; Ruas, Margarida; Pan, Zui; Cheng, Xiaotong; Arredouani, Abdelilah; Hao, Xuemei; Tang, Jisen; Rietdorf, Katja; Teboul, Lydia; Chuang, Kai-Ting; Lin, Peihui; Xiao, Rui; Wang, Chunbo; Zhu, Yingmin; Lin, Yakang; Wyatt, Christopher N.; Parrington, John; Ma, Jianjie; Evans, A. Mark; Galione, Antony and Zhu, Michael X.
Nature, 459(7246) (pp. 596-600)
Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca2+ release and apoptosis (2008-02-19)
Szado, Tania; Vanderheyden, Veerle; Parys, Jan B.; De Smedt, Humbert; Rietdorf, Katja; Kotelevets, Larissa; Chastre, Eric; Khan, Farid; Landegren, Ulf; Söderberg, Ola; Bootman, Martin D. and Roderick, H. Llewelyn
Proceedings of the National Academy of Sciences of the United States of America, 105(7) (pp. 2427-2432)
Regulation of InsP3 receptor activity by neuronal Ca2+-binding proteins (2004-01-28)
Kasri, Nael Nadif; Holmes, Anthony M.; Bultynck, Geert; Parys, Jan B.; Bootman, Martin; Rietdorf, Katja; Missiaen, Ludwig; McDonald, Fraser; De Smedt, Humbert; Conway, Stuart J.; Holmes, Andrew B.; Berridge, Michael J. and Roderick, H. Llewelyn
The EMBO Journal, 23(2) (pp. 312-21)
Tissue Specificity: Store-Operated Ca2+ Entry in Cardiac Myocytes (2017)
Bootman, Martin D. and Rietdorf, Katja
In: Groschner, K.; Graier, W. and Romanin, C. eds. Store-Operated Ca²⁺ Entry (SOCE) Pathways. Advances in Experimental Medicine and Biology (pp. 363-387)
ISBN : 978-3-319-57732-6 | Publisher : Springer
How does fat cause heart diseases? Effects of epicardial adipocytes on cardiomyocyte signalling and contractility (2016-09)
Masoud, Said; Bootman, Martin D.; McDonald, Fraser; MacQueen, Hilary and Rietdorf, Katja
In : 14th International Meeting of the European Calcium Society (25-29 Sep 2016, Valladolid, Spain)
Can we use chemical-induction of ageing to develop a model of cardiac ageing? (2016-09)
Masoud, Said; Bootman, Martin D.; McDonald, Fraser and Rietdorf, Katja
In : 14th International Meeting of the European Calcium Society (25-29 Sep 2016, Valladolid, Spain)
Calcium phosphate crystals found in atherosclerotic plaques induce cytotoxic effects via loss of cellular calcium homeostasis. (2016-09)
Sharma, Kumar; Rietdorf, Katja; Proudfoot, Diane; McDonald, Fraser and Bootman, Martin D.
In : 14th International Meeting of the European Calcium Society (25-29 Sep 2016, Valladolid, Spain)
Mibefradil; a T-type calcium channel blocker as a potential anti-cancer agent. (2016-09)
Matheou, Chrysanthi; Chandler, Stephen; Crea, Francesco; Faria, Nuno; Powell, Jonathan; McDonald, Fraser; Rietdorf, Katja and Bootman, Martin D.
In : 14th International Meeting of the European Calcium Society (25-29 Sep 2016, Valladolid, Spain)
The sources and characteristics of calcium signals determine whether autophagy is up- or downregulated. (2016-09)
Chehab, Tala; Rietdorf, Katja; Parys, Jan B.; Bultynck, Geert and Bootman, Martin D.
In : 14th International Meeting of the European Calcium Society (25-29 Sep 2016, Valladolid, Spain)
Chemically inducing ageing in neonatal rat ventricular myocytes (2016-03)
Masoud, Said; Bootman, Martin; McDonald, Fraser and Rietdorf, Katja
In : Evolution brings Ca2+ and ATP together to control life and death (16-17 Mar 2016, Kavli Royal Society Centre, Chicheley Hall, Newport Pagnell)
How cells outside the heart can affect the heart beat: The role of pulmonary vein sleeve cells for the development of atrial fibrillation (2016-03)
Rietdorf, Katja; Masoud, Said; McDonald, Fraser and Bootman, Martin
In : Evolution brings Ca2+ and ATP together to control life and death (16-17 Mar 2016, Kavli Royal Society Centre, Chicheley Hall, Newport Pagnell)
Intracellular calcium: a dual role in autophagy (2016)
Chehab, Tala; Rietdorf, Katja; Parys, Jan B.; Bultynck, Geert and Bootman, Martin
In : Evolution brings Ca2+ and ATP together to control life and death (16-17 Mar 2016, Chichley Hall, Newport Pagnell)
Calcium phosphate crystals observed during atherosclerosis have a cytotoxic effect that results in loss of calcium homeostasis (2016)
Sharma, Kumar; Rietdorf, Katja; Proudfoot, Diane; McDonald, Fraser and Bootman, Martin
In : Evolution brings Ca2+ and ATP together to control life and death (16-17 Mar 2016, Kavli Royal Society Centre, Chicheley Hall, Newport Pagnell)
Interactions between epicardial adipose tissue and cardiomyocytes: results from a 3D co-culture system (2015-12-17)
Rietdorf, Katja and MacQueen, Hilary
In : Pharmacology 2015 (British Pharmacological Society) (15-17 Dec 2015, London)
How does fat cause heart diseases? Effects of epicardial adipocytes on cardiomyocyte signalling and contractility (2015)
Rietdorf, Katja; MacQueen, Hilary and Bootman, Martin
In : Physiology 2015 (6-8 Jul 2015, Cardiff)
Ageing-induced ultrastructural changes of mitochondria of pulmonary vein sleeve cells (2015)
Masoud, Said; McDonald, Fraser; Bootman, Martin and Rietdorf, Katja
In : Physiology 2015 (6-8 Jul 2015, Cardiff)
Inhibition of calcium release from InsP3Rs triggers autophagy (2015)
Chehab, Tala; Rietdorf, Katja; Parys, Jan; Bultynck, Geert and Bootman, Martin
In : Physiology 2015 (6-8 Jul 2015, Cardiff)
Effect of calcium-phosphate crystals on intracellular calcium homeostasis and viability of smooth muscle cell (2015)
Sharma, G.; Rietdorf, K.; Proudfoot, D.; McDonald, F. and Bootman, M.
In : Physiology 2015 (6-8 Jul 2015, Cardiff, UK)
Intracellular calcium has a dual role in the regulation of autophagy (2015)
Chehab, Tala; Rietdorf, Katja; Parys, Jan B.; Bultynck, Geert and Bootman, Martin
In : 6th ECS Workshop: Calcium and Cell Fate (21-24 Jun 2015, Seillac, France)
How cells outside the heart can affect the heart beat: The role of pulmonary vein sleeve cells for the development of atrial fibrillation (2015)
Rietdorf, Katja; Masoud, Said; McDonald, Fraser and Bootman, Martin
In : Gordon Conference on Calcium Signalling (7-12 Jun 2015, Newry, Maine, USA)
Spontaneous Ca2+ signalling and ultrastructural changes in pulmonary vein sleeve cells during ageing – risk factors for atrial fibrillation? (2014-10-09)
Masoud, Said; Bootman, Martin D.; McDonald, Fraser and Rietdorf, Katja
In : Calcium Signalling: The Next Generation (9-10 Oct 2014, London, UK)
Inhibition of InsP3 receptor signalling induces autophagy (2014-10-09)
Chehab, Tala; Rietdorf, Katja; Parys, Jan B.; Bultynck, Geert and Bootman, Martin D.
In : Calcium Signalling: The Next Generation (9-10 Oct 2014, London, UK)
Novel improved Ca2+ indicator dyes on the market-a comparative study of novel Ca2+ indicators with fluo-4 (2014-10-09)
Rietdorf, Katja; Chehab, Tala; Allman, Sarah and Bootman, Martin D.
In : Calcium Signalling: The Next Generation (9-10 Oct 2014, London, UK)
A comparative study into the ultrastructure changes of atrial myocytes, pulmonary vein sleeve cells and ventricular myocytes during ageing (2014-10-09)
Masoud, Said R.; McDonald, Fraser; Bootman, Martin D. and Rietdorf, Katja
In : Calcium Signalling: The Next Generation (9-10 Oct 2014, London, UK)
Spontaneous Ca2+ signalling and ultrastructural changes in pulmonary vein sleeve cells during ageing – risk factors for atrial fibrillation? (2014-09)
Rietdorf, Katja; Masoud, Said; McDonald, Fraser and Bootman, Martin
In : 13th International Meeting of the European Calcium Society (13-17 Sep 2014, Aixe-en-Provence, France)
Spontaneous Ca2+ signalling in pulmonary vein sleeve cells increases during ageing (2014-06)
Masoud, Said; Bootman, Martin and Rietdorf, Katja
In : Physiology 2014 (30 Jun - 02 Jul 2014, London)
Inhibition of InsP3 receptor signalling induces autophagy (2014)
Chehab, Tala; Rietdorf, Katja; Parys, Jan; Bultynck, Geert and Bootman, Martin
In : 13th International Meeting of the European Calcium Society (13-17 Sep 2014, Aix-en-Provence, France)
In vitro assessment of alveolar macrophage responses to inhaled particulate medicines (2014)
Hutter, V.; Murnane, D.; Rietdorf, K.; Fowler, D.; Walton, C. and Bootman, M.
In : Drug Delivery to the Lungs (DDL25) (10-12 Dec 2014, Edinburgh)