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  2. New BioRxiv paper shows the cellular consequences of N-glycanase 1 deficiency

New BioRxiv paper shows the cellular consequences of N-glycanase 1 deficiency

Former OU PhD student Sarah Needs, Drs Martin Bootman and Sarah Allman have published a new BioRxiv preprint describing the cellular consequences of a rare genetic disease that is often called NGLY1 (more formally N-glycanase 1 deficiency) that leads to developmental delay and neurological issues. The study shows that cells with NGLY1 deficiency have increased autophagy ('self-eating'; a cell survival process that can also lead to cell death) potentially as mechanism to cope with accumulation of misfolded proteins.

Read the full paper here