Available online
Description
The programme examines the methodology involved in sorting out environmental from genetic factors. Congenital dislocation of the hip is taken as a case study.
The programme examines the methodology involved in sorting out environmental from genetic factors. Congenital dislocation of the hip is taken as a case study.
| Module code and title: | S299, Genetics |
|---|---|
| Item code: | S299; 15 |
| First transmission date: | 04-10-1976 |
| Published: | 1976 |
| Rights Statement: | |
| Restrictions on use: | |
| Duration: | 00:24:13 |
| + Show more... | |
| Producer: | Jean Nunn |
| Contributors: | R J Berry; Ruth Wynne-Davies |
| Publisher: | BBC Open University |
| Keyword(s): | Congenital hip dislocation; Environment; Foetus; Genetics; Human phenotypes; Oestrogen |
| Footage description: | Film shots of Olympic athletes on parade. R.J. Berry introduces the programme. He points out some of the ways in which genetic variation in humans can be studied. Ruth Wynne-Davies explains what CDH (Congenital Dislocation of the Hip) is and how it is diagnosed. Film shots of a 53 year old woman with untreated CDH. Wynne-Davies uses a skeletal pelvis and femur to explain, in detail, what goes wrong in CDH. She points out the two possible mechanisms for the disease. Shots of X-rays of diseased and normal hips. Film shots of a newborn baby having its hips tested for the presence of CDH. Shots of the baby being placed into a Malmo splint as part of its treatment. Commentary by Wynne-Davies. Berry discusses the effect of oestrogen on CDH for children in the womb. He goes on to discuss Marfan's syndrome, a single gene effect. Shots of Abraham Lincoln, a possible sufferer of this syndrome. Berry briefly discusses Ehlers Danlos syndrome (anomalies of connective tissue) which results in joint laxity. Ruth Wynne-Davies explains what joint laxity is and tests three young children of various ages (2 and a half - 4) for this condition. She then uses a graph to compare joint laxity in children with CDH and joint laxity in normal children. Berry looks at a human pedigree diagram to see how joint laxity ties in with CDH. He then uses two mice to point out how depth of the hip acetabulum affects CDH. Mouse pelvic bones are used to make the point that this is not a single gene effect. Wynne-Davies with X-rays of a human pelvis showing a normal and a diseased joint. She points out that the CE angle (Wigert angle) of the pelvis is smaller in parents of CDH children. Berry with a graph which shows results for a large population of parents and children. The graph indicates that acetabular depth is a many gene effect. Berry sums up. |
| Master spool number: | 6HT/72157 |
| Production number: | 00525_1183 |
| Videofinder number: | 1004 |
| Available to public: | no |
