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Description
The events leading up to the development of norethindrone, one of the most popular of the oral contraceptive drugs.
The events leading up to the development of norethindrone, one of the most popular of the oral contraceptive drugs.
| Module code and title: | S304, The nature of chemistry |
|---|---|
| Item code: | S304; 26 |
| First transmission date: | 25-08-1977 |
| Published: | 1977 |
| Rights Statement: | |
| Restrictions on use: | |
| Duration: | 00:24:00 |
| + Show more... | |
| Producer: | David Jackson |
| Contributors: | Albert Bowers; David Roberts; Carl Djerassi; Arthur Birch |
| Publisher: | BBC Open University |
| Keyword(s): | Chemistry; Contraceptives; Drug; Hormones; Norethindrone; Oral; Progesterone; Syntex |
| Footage description: | Footage - Molecular diagram of norethindrone & progesterone (1'38"-2'08") - Molecular diagram of testosterone, androsterone, progesterone & estrone (2'53"-3'11") - Molecular diagram of estrone & progesterone (3'32"-3'55") - Drawing of inactive and active progesterone (4'10"-4'42") - Molecular diagram of strophanthidin & 19-norisoprogesterone (5'21"-6'01") - Molecular diagram of Ehrenstein's compound compared with progesterone (6'34"-6'49") - Picture of Prof. Arthur Birch (7'23"-7'39") - Molecular diagrams of corticoid hormones. Experiment showing the joint action of sodium and alcohol on toluene which adds two hydrogens to toluene. Reduction of phenols in liquid ammonia. Birch reduction (7'54"-12'21") - Molecular diagram showing the reduction of estradiol to dihydroether, then hydrolysed with acid to give 19-nortestosterone (13'27"-13'58") - Prof. Leopold Ruzicka's hormone analogues & Grignard reactions (15'33"-16'10") - Molecular diagram of 17-ethynyltestosterone (16'17"-16'30"). Molecular diagram of norethindrone (17'19"-17'39") - Production of an enol ether, oxidation of the hydroxyl group using chromium trioxide in glacial acetic acid (18'08"-20'44") - Ether extraction and evaporation and the addition of the ethynyl group using potassium ethynide. Flask of pure norethindrone and its molecular structure (21'26"-22'53"). |
| Master spool number: | 6HT/72201 |
| Production number: | 00525_1234 |
| Videofinder number: | 909 |
| Available to public: | no |
