Available online
Description
This programme looks at the immunological significance of the complex of genes known as the major histocompatibility complex.
This programme looks at the immunological significance of the complex of genes known as the major histocompatibility complex.
| Module code and title: | S322, Biochemistry and molecular biology |
|---|---|
| Item code: | S322; 16 |
| First transmission date: | 13-10-1977 |
| Published: | 1977 |
| Rights Statement: | |
| Restrictions on use: | |
| Duration: | 00:24:28 |
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| Producer: | James Burge |
| Contributors: | Hugh McDevitt; Peter Medawar; Martin Raff; Rolf Zinbernagel |
| Publisher: | BBC Open University |
| Keyword(s): | Antigens; Immunology; Major histocompatibility; Medawar; T-cells |
| Footage description: | Martin Raff introduces the programme. Film of a kidney transplant operation. Peter Medawar points out that graft rejection is an immunological phenomenon. Martin Raff goes on to discuss how the major histocompatibility complex (MHC) acts in graft rejection. Martin Raff, using schematic diagrams, looks at the MHC complex in the mouse. Over film shots of experiments with rabbits and then with mice, Raff explains how the so called immune response genes were discovered. Animated diagrams are also used by Raff in his discussion. Hugh McDevitt, using a blackboard, briefly explains how he discovered the I region in MHC. Raff points out some other immunological functions which were found to be associated with the I region in the mouse. Rolf Zinbernagel explains, with the aid of diagrams, how the experiment conducted by himself and Peter Doherty in 1974 mapped the MHC gene complex on the 17th chromosome of the mouse. Raff goes on to discuss several hypotheses which might explain associate of recognition in terms of molecular biology. Several diagrams help illustrate his discussion. Over animated diagrams, Martin Raff sums up the state of knowledge so far of the genetic regulation of MHC. Hugh McDevitt, using diagrams, discusses possible involvement in disease susceptibility of the MHC system. Martin Raff sums up the programme. |
| Master spool number: | 6HT/72549 |
| Production number: | 00525_1273 |
| Videofinder number: | 1023 |
| Available to public: | no |
