Available online
Description
The chemistry of amide hydrolysis in the test tube and from enzyme-catalysed reactions.
The chemistry of amide hydrolysis in the test tube and from enzyme-catalysed reactions.
| Module code and title: | S246, Organic chemistry |
|---|---|
| Item code: | S246; 11 |
| First transmission date: | 1981 |
| Published: | 1981 |
| Rights Statement: | |
| Restrictions on use: | |
| Duration: | 00:25:00 |
| + Show more... | |
| Producer: | Roger Jones |
| Contributor: | Mike Page |
| Publisher: | BBC Open University |
| Keyword(s): | Amide; Carboxypeptidase A; Enzyme-catalyst reactions; Harvard University America; Hydrolisis; Peptide bond |
| Footage description: | Footage - Films of proteins, enzymes, hormones, antibodies. Formula of penicillin (0'39"-1'39") - Animation of amide bond formation/cleavage (1'53"-2'54") - Violent chemical reaction of acid chloride with water (3'15"-3'19") - Animation of acid catalysed reaction and base catalysed reaction (3'41"-3'54") - Graphic of catalysed hydrolysed hydrolysis of amides (4'30"-4'53") - Chemical reaction of hydrolysis of amides. Experiment with spectrophotometre. Graph showing rate of hydrolysis (5'07"-6'15") - Graphic of formula. Experiment of bisulphite addition compound of benzaldehyde and sodium bisulphite forming a precipitate. Chemical formula of base promoted hydrolysis of amides (6'32"-8'18") - Mass spectrophotometre room at Huddersfield Polytechnic. Graphic of formula of isotopic exchange. Mass spectrometer. Graph of isotopic hydrolysis. Formula showing formation of tetrahedral intermediate (8'42"-12'33") h. Animation of formula and molecules recapping of the mechanism of acid hydrolysis (12'33"-15'04") - Model of carboxypeptidase A. Animation of mechanism of action of carboxypeptidase A (16'25"-18'23") - Formulas of nucleophiles (18'30 "-18'59") - Rotating model of an enzyme (19'20"-19'45"). |
| Master spool number: | HOU3775 |
| Production number: | HOU3775 |
| Videofinder number: | 1957 |
| Available to public: | no |
