Available online
Description
Drug molecules may be as similar at the right and left hand but in the body this difference can be of vital importance.
Drug molecules may be as similar at the right and left hand but in the body this difference can be of vital importance.
| Module code and title: | S246, Organic chemistry |
|---|---|
| Item code: | S246; 02; 1991 |
| First transmission date: | 17-03-1991 |
| Published: | 1991 |
| Rights Statement: | |
| Restrictions on use: | |
| Duration: | 00:25:00 |
| + Show more... | |
| Producer: | Barrie Whatley |
| Contributors: | Alan Bassindale; Rob Cooke |
| Publisher: | BBC Open University |
| Keyword(s): | Cell wall; Chirality discovery; Drug protection; Glaxo; Penicillin |
| Subject terms: | Chemistry, organic; Chirality |
| Footage description: | Footage - Picture of Biot (1'28"-1'33") - Crystal (1'34"-1'48") - Demonstration of polarisation (1'49"-3'10") - Picture of Louis Pasteur (3'11"-3'16") Model of chiral molecule (4'11"-4'30") - Vertical split screen to reflect chiral molecule (4'31"-4'53") - Graphic of enantiomers (4'54"-5'10") - Montage of newspaper headings (6'16"-6'33") - Thalidomide children playing/eating (6'34"-6'53") - Enzymatix (6'54"-7'13") - Making biocatalyst in laboratory to synthesise substrates and produce single chiral product (8'15"-9'30") - Chemical formulas on a board. Alan Bassindale & Chris Evans describe resolution process using enzymes to produce optically pure gamma lactams & amino acids (9'31"-12'20") - Molecular graphic (12'33"-12'47") - Barry Sharpless describing the design of the first useful synthetic catalyst. Graphics sequence of propranolol synthesis (12'48"-17'30"). Glaxo laboratory. Rob Cooke describing how computers help to understand drug interactions and design better drugs with computer generated molecular graphics of interactions between drug and protein, glycine, inverting the chirality of L-alanine to create D-alanine, bacteria cell wall, penicillin-G on top oft ri-peptide & x-ray diffraction structures of penicillin and it's target enzyme (17'31"-23'57"). |
| Master spool number: | HOU6900 |
| Production number: | FOUS625L |
| Videofinder number: | 3766 |
| Available to public: | no |
