Available online
Description
The programme uses sickle cell disease as a vehicle to introduce a basic genetic vocabulary and show how defects in DNA give rise to mutations.
The programme uses sickle cell disease as a vehicle to introduce a basic genetic vocabulary and show how defects in DNA give rise to mutations.
| Module code and title: | S299, Genetics |
|---|---|
| Item code: | S299; 02 |
| First transmission date: | 01-03-1976 |
| Published: | 1976 |
| Rights Statement: | |
| Restrictions on use: | |
| Duration: | 00:24:00 |
| + Show more... | |
| Producer: | Roger Jones |
| Contributors: | Peter S. Carlson; Mike Tribe; Robert Whittle |
| Publisher: | BBC Open University |
| Keyword(s): | Antibiotic resistance; Bacteria; DNA; Fruit flies; Heritable change; Micro-organisms; Mutation; Nutritional mutants; Viruses |
| Footage description: | Film shots taken through a light microscope show red blood cells affected by sickle cell anaemia. Commentary by Garard Green introduces the programme. Two negro patients with sickle cell anaemia describe their symptoms. Prof. J. White discusses the condition in these two patients. He uses an X-ray photograph of the pelvis of one of the patients to illustrate one of the effects of the disease. J. White uses an animated family tree diagram to discuss and trace the inheritance of the disease in patients with sickle cell anaemia. Using micrographs, electron micrographs and a demonstration, White explains how the red blood cells become deformed in patients with the disease. Garard Green uses models of the haemoglobin molecule to point out differences between normal and sickle haemoglobin. Green goes on to explain how the genetic code in DNA is made up. Animations illustrate his points. Robert Whittle explains why drosophila is such a good organism for genetic research. Several shots of fruit flies. Whittle goes on to describe how the first white eyed mutant was discovered at Columbia University. Whittle goes on to discuss the use of mutagens to induce mutant offspring in drosophila. Close up shots of several drosophila mutants. Commentary by Whittle points out their features. Using film shots of live drosophila, Whittle explains to students how to determine sex and mutant characteristics for the home experiments. |
| Master spool number: | 6HT/71869 |
| Production number: | 00525_1170 |
| Videofinder number: | 990 |
| Available to public: | no |
