Available online
Description
Max Perutz introduces the programme. Using a low resolution molecular model, he points out the structure of haemoglobin. Film of oxygenated and de-oxygenated blood inside tonometers. Anna Furth poi...nts out the colour changes which take place as blood becomes saturated with oxygen. She goes on to show an absorption spectrum of haemoglobin (animated graph) and explains the results. Perutz examines the sigmoid oxygen equilibrium curves and explains their physiological purpose. He goes on to show, with the aid of graphics, how this accounts for CO2 uptake and transport from tissue to lung. Perutz recalls the research pathway which over a period of many years led him to arrive at an atomic model of the haemoglobin molecule. Shots of atomic models, optical micrographs and X-ray diffraction pictures help to illustrate his points. Using animated atomic models of haemoglobin, Perutz demonstrates the physiological processes, oxygen/CO2 uptake and transfer, which are made possible by the configuration of the molecule. Perutz demonstrates, using a high resolution atomic model of haemoglobin, an optical micrograph of red blood cells and diagrams, how a minute change in the chemistry of the haemoglobin molecule brings about the disease sickle cell anaemia.
Max Perutz introduces the programme. Using a low resolution molecular model, he points out the structure of haemoglobin. Film of oxygenated and de-oxygenated blood inside tonometers. Anna Furth poi...nts out the colour changes which take place as blood becomes saturated with oxygen. She goes on to show an absorption spectrum of haemoglobin (animated graph) and explains the results. Perutz examines the sigmoid oxygen equilibrium curves and explains their physiological purpose. He goes on to show, with the aid of graphics, how this accounts for CO2 uptake and transport from tissue to lung. Perutz recalls the research pathway which over a period of many years led him to arrive at an atomic model of the haemoglobin molecule. Shots of atomic models, optical micrographs and X-ray diffraction pictures help to illustrate his points. Using animated atomic models of haemoglobin, Perutz demonstrates the physiological processes, oxygen/CO2 uptake and transfer, which are made possible by the configuration of the molecule. Perutz demonstrates, using a high resolution atomic model of haemoglobin, an optical micrograph of red blood cells and diagrams, how a minute change in the chemistry of the haemoglobin molecule brings about the disease sickle cell anaemia.
| Module code and title: | S322, Biochemistry and molecular biology |
|---|---|
| Item code: | S322; 01 |
| First transmission date: | 03-03-1977 |
| Published: | 1977 |
| Rights Statement: | |
| Restrictions on use: | |
| Duration: | 00:25:03 |
| + Show more... | |
| Producer: | Roger Jones |
| Contributors: | Anna Furth; Max Perutz |
| Publisher: | BBC Open University |
| Keyword(s): | Exchange; Gas transport; Haemoglobin; Sickle cell disease; Structure and function |
| Master spool number: | 6HT/72408 |
| Production number: | 00525_1258 |
| Videofinder number: | 1006 |
| Available to public: | no |
