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Max Perutz introduces the programme. Using a low resolution molecular model, he points out the structure of haemoglobin. Film of oxygenated and de-oxygenated blood inside tonometers. Anna Furth poi...nts out the colour changes which take place as blood becomes saturated with oxygen. She goes on to show an absorption spectrum of haemoglobin (animated graph) and explains the results. Perutz examines the sigmoid oxygen equilibrium curves and explains their physiological purpose. He goes on to show, with the aid of graphics, how this accounts for CO2 uptake and transport from tissue to lung. Perutz recalls the research pathway which over a period of many years led him to arrive at an atomic model of the haemoglobin molecule. Shots of atomic models, optical micrographs and X-ray diffraction pictures help to illustrate his points. Using animated atomic models of haemoglobin, Perutz demonstrates the physiological processes, oxygen/CO2 uptake and transfer, which are made possible by the configuration of the molecule. Perutz demonstrates, using a high resolution atomic model of haemoglobin, an optical micrograph of red blood cells and diagrams, how a minute change in the chemistry of the haemoglobin molecule brings about the disease sickle cell anaemia.
Metadata describing this Open University video programme
Module code and title: S322, Biochemistry and molecular biology
Item code: S322; 01
First transmission date: 03-03-1977
Published: 1977
Rights Statement:
Restrictions on use:
Duration: 00:25:03
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Producer: Roger Jones
Contributors: Anna Furth; Max Perutz
Publisher: BBC Open University
Keyword(s): Exchange; Gas transport; Haemoglobin; Sickle cell disease; Structure and function
Master spool number: 6HT/72408
Production number: 00525_1258
Videofinder number: 1006
Available to public: no