Available online
Description
This programme presents the latest ideas on how DNA and histone is organised within chromosomes.
This programme presents the latest ideas on how DNA and histone is organised within chromosomes.
| Module code and title: | S322, Biochemistry and molecular biology |
|---|---|
| Item code: | S322; 11 |
| First transmission date: | 04-08-1977 |
| Published: | 1977 |
| Rights Statement: | |
| Restrictions on use: | |
| Duration: | 00:25:00 |
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| Producer: | Roger Jones |
| Contributors: | Morton Bradbury; Francis Crick; Jean Thomas |
| Publisher: | BBC Open University |
| Keyword(s): | Chromatin; Chromosomes; DNA; Histones; Neutron scattering |
| Footage description: | Francis Crick introduces the programme. He explains what chromatin is and compares the amounts found in the cells of various enkaryotic organisms. Still shots and animated diagrams illustrate his points. Crick goes on to describe briefly how the packages its chromatin during mitosis. Film of a plant cell during mitosis. Crick works out the ratio of length of DNA in a chromosome to that of the chromosome itself. He poses the question of how the DNA and histone proteins in chromosomes are folded to fit. Electron micrographs help to illustrate his points. Jean Thomas, using models, animations and electron microgranhs describes how by biochemical techniques the biochemically distinguishable units of histone wrapped in DNA strands were determined. These results gave a general model for first order packing of DNA. Morton Bradbury describes how the technique of neutron scattering exploits the physical differences between DNA and protein to build up a picture of the spatial organisation of the repeating unit. Bradbury uses a graphics board and models to illustrate the principles of this tehnique. He goes on to examine the composition and structure of the histone core as determined by the neutron scattering technique. He uses bead models to help illustrate his points. Francis Crick explains, with the aid of models, how the basic core particles of chromatin can be organised into higher order structures. He quotes evidence from electron microscopy to illustrate his points. |
| Master spool number: | 6HT/72466 |
| Production number: | 00525_1268 |
| Videofinder number: | 1018 |
| Available to public: | no |
