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Cell and molecular biomedicine

A culture of human astrocytes visualised by fluorescence microscopy and stained with fluorescent markers for F-actin (red), focal adhesion kinase (green) and DNA (blue). (Courtesy of Chris Lancashire)

Our research focuses on the molecular and cellular processes underlying health, ageing and disease. We have a particular focus on diseases that have a significant impact on society. Our aim is to identify both novel therapeutic targets and innovative therapeutic agents for these conditions.

Key themes of our research include:

  • Anti-cancer therapies
  • Ageing
  • Appetite and reproductive physiology
  • Cardiovascular disorders, including those affecting the cerebrovascular network such as multiple sclerosis and stroke, and those affecting the heart such as cardiac arrhythmias
  • Cell signalling and systems biology
  • Inflammation and immunity
  • Mechanisms underlying ageing at the organismal and cellular level
  • Molecular mechanisms of disease.

Qualifications available:

MPhil or PhD

Fees:

For detailed information on current fees visit Fees and funding.

Entry requirements:

Minimum 2:1 (or equivalent) or an appropriate first degree and postgraduate qualification

Potential research projects

Current/recent research projects

  • Regulation of cellular autophagic and apoptotic cell death
  • Werner Syndrome-related exonucleases in Drosophila; roles in nuclear and mitochondrial genome stability
  • Changes in signalling and ultra-structure in cardiomyocytes during ageing
  • Developing tissue engineered implantable devices for surgical repair of the nervous system
  • Analysis of changes in gastrointestinal appetite hormones and hypothalamic circuitry during pregnancy and lactation
  • Development of novel, robust 3D CNS tissue models for neurobiological studies and drug discovery
  • The response of human brain and endothelium and astrocytes to vasoactive mediators
  • Elucidating the molecular mechanisms contributing to blood-brain barrier breakdown in multiple sclerosis

Potential supervisors

Further information

If you have an enquiry specific to this research area please contact:

Name:
Administrative support
Email:
STEM-LHCS-Admin@open.ac.uk
Phone:
+44 (0)1908 655808

For general enquiries please contact the Research Degrees Team via the link under 'Your Questions' on the right of the page.